![]() Effect of androgen on different biochemical constituents of human semen. ![]() 2004 41:72-80.).Īnother study with a low sample size (eight healthy volunteers with azoospermia) illustrated that administration of testosterone propionate over a four-week period did not change the level of ascorbic acid in human semen even after 12 injections ( 8 8 Roy S, Das RP, Taneja SL. Protective action of an anti-oxidant (L-Ascorbic acid) against genotoxicity and cytotoxicity in mice during p-DAB-induced hepatocarcinogenesis. The protective effects of ascorbic acid on p-dimethylaminoazobenzene induced genotoxicity and cytotoxicity have also been confirmed in mice ( 7 7 Surjyo B, Anisur KB. Evaluation of sperm DNA peroxidation in fertile and subfertile dogs. One before-after study evaluated the effects of vitamins C and E (each one 500 mg/day) and demonstrated no efficacy of these antioxidants on DNA peroxidation in fertile and subfertile dogs but, this controversial result could have been due to the very low sample size ( 6 6 Lopes-Santiago BV, Monteiro GA, Bittencourt R, Arduino F, Ovidio PP, et al. Protective effect of vitamins e and C on endosulfan-induced reproductive toxicity in male rats. Other antioxidants like vitamin C (ascorbic acid) and vitamin E have been proved to ameliorate the oxidative stress and sperm toxicity induced by endosulfan in rats ( 5 5 Takhshid MA, Tavasuli AR, Heidary Y, Keshavarz M, Kargar H. Chemoprotective effect of lipoic acid against cyclophosphamide-induced changes in the rat sperm. ![]() established the effect of lipoic acid (an antioxidant like substance) in improvement of semen quality and reducing the oxidative stress and DNA damage induced by cyclophosphamide in rats ( 4 4 Selvakumar E, Prahalathan C, Sudharsan PT, Varalakshmi P. The treatment of infertility requires a multi-faceted therapeutic approach, consisting of improvements in environmental and occupational risk factors, nutritional imbalances, antioxidants, medical therapies, surgeries, and assisted reproductive technology (ART). Infertility is an important issue for couples with sometimes severe consequences. Mechanisms of male infertility: role of antioxidants. 1995 332:281-5.) and impaired sperm function has been considered as the most common cause of infertility ( 3 3 Sheweita SA, Tilmisany AM, Al-Sawaf H. Decline in semen quality among fertile men in Paris during the past 20 years. In addition, the quality of semen in men has declined during the past few decades ( 2 2 Auger J, Kunstmann JM, Czyglik F, Jouannet P. Infertility among couples in a population-based study in Iran: prevalence and associated risk factors. Infertility has had an increasing trend during recent decades in Iran ( 1 1 Safarinejad MR. The overall prevalence of infertility is up to 15% of couples and in half of the cases male factor is involved. Ascorbic acid can play a role as adjuvant treatment after varicocelectomy in infertile men.Īscorbic Acid Varicocele Infertility, Male Semen Analysis Vitamin C was also an independent factor in predicting motility and normal morphology after surgery. Considering the values prior to surgery as covariate, vitamin C was not effective on sperm count (P=0.091) but it improved sperm motility (P=0.016) and morphology (P<0.001) even after excluding the confounding effect of age (P=0.044 and P=0.001, respectively). Vitamin C group had statistically significant better normal motility (20.8 vs. The mean age (±SD) of participants was 27.6±5.3 years. Univariate general linear model and stepwise linear regression were used in analysis. Mean sperm count, motility, and morphology index of two semen analyses (before and after surgery) were compared between the two groups. After surgery, the intervention group received vitamin C (250 mg bid) and the control group received placebo for three months. In a double blind randomized controlled clinical trial, 115 men with infertility and clinical varicocele with abnormal semen analyses were recruited. The most important seminal antioxidant is vitamin C but recent studies about the effects of vitamin C on spermatogenesis are controversial therefore, we decided to evaluate its role after varicocelectomy. Varicocele is one of the most common causes of male infertility and spontaneous pregnancy rate after varicocelectomy is only about 30%.
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